The Power of Suggestion and the Problematic Insignificance of Significance
Mad in America
JULY 23, 2024
B ased upon the 2022 meta-analysis by Stone, et al. , a difference of 1.8 points on a measure of depression between placebo (average depression score reduction of 8.0 points) and antidepressant (average depression score reduction of 9.8 points) was found. This statistically significant difference is so small it is undetectable in real life; it is not even an average small, clinically insignificant difference.
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