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Placebo Effect—Not Antidepressants—Responsible for Depression Improvement

Mad in America

In a study of fluoxetine (Prozac) for adolescents, researchers found that the placebo effect predicted good outcomes, but the actual drug treatment did not. After accounting for “treatment guess” (those who figured out that they were receiving an intervention rather than placebo), the drug was not effective in depression treatment.

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Much of U.S. Healthcare Is Broken: How to Fix It (Chapter 2, Part 2)

Mad in America

S ome of the following studies appeared in my book Antidepressants: Science, Magic or Marketing , 1 and in the next section, I will report on some of the more recent depression treatment outcome studies. What is the power of cognitive behavioral therapy (CBT) in treating depression versus drug treatment efficacy?