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Placebo Effect—Not Antidepressants—Responsible for Depression Improvement

Mad in America

In a study of fluoxetine (Prozac) for adolescents, researchers found that the placebo effect predicted good outcomes, but the actual drug treatment did not. After accounting for “treatment guess” (those who figured out that they were receiving an intervention rather than placebo), the drug was not effective in depression treatment.

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Two Out of Three Find Antidepressant Effects Not Worth Burdens

Mad in America

The study, titled “Estimating the smallest worthwhile difference of antidepressants: a cross-sectional survey,” delves into the challenging decisions faced by individuals considering SSRI and SNRI antidepressants, which are common treatments for depression. Only a third of patients are satisfied with these medications.

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Stop Using Antidepressants Except for “the Most Severe Depression,” Experts Say

Mad in America

Take, for instance, a recent meta-analysis finding that exercise is just as good as antidepressants at treating mild to moderate depression —and that adding drugs to the regimen does not improve outcomes. Dixon, M., & Marshall-Andrews, M.

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The New York Times Is Now Engulfed in the STAR*D Scandal

Mad in America

This was a story of a great medical advance, and the announced results from the STAR*D trial, heralded by the NIMH as the “largest and longest study ever done to evaluate depression treatment,” fit into that story of medical progress, for it told of 70% of depressed patients becoming “symptom free” after repeated treatments with antidepressants.

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Summing up the STAR*D Scandal: The Public was Betrayed, Millions were Harmed, and the Mainstream Media Failed Us All

Mad in America

American psychiatry has weathered the crisis; it will not have to confront a public stunned by news of how the oft-cited 67% cumulative remission rate, in the largest and longest study ever done to evaluate depression treatment,” was born of scientific misconduct.

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Adding Antipsychotics Worsens Outcomes in Psychotic Depression

Mad in America

Antipsychotics in the maintenance phase for psychotic depression. Published online November 6, 2023. link] (Full Text) The post Adding Antipsychotics Worsens Outcomes in Psychotic Depression appeared first on Mad In America. Al-Wandi, A., Landén, A. M., & Nordenskjöld, A. Acta Psychiatrica Scandinavica.

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STAR*D: The Harms of Orchestrated Psychiatric Fraud

Mad in America

The first NIMH treatment outcome study , which was published in 1989, found the drug treatment (imipramine) to be no more effective than placebo when measures were taken after three months of treatment. Within days of learning of the misreporting of cancer research at Dana Farber, that story was on page one of the Times.