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Stop Using Antidepressants Except for “the Most Severe Depression,” Experts Say

Mad in America

Take, for instance, a recent meta-analysis finding that exercise is just as good as antidepressants at treating mild to moderate depression —and that adding drugs to the regimen does not improve outcomes.

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Placebo Effect—Not Antidepressants—Responsible for Depression Improvement

Mad in America

In a study of fluoxetine (Prozac) for adolescents, researchers found that the placebo effect predicted good outcomes, but the actual drug treatment did not. After accounting for “treatment guess” (those who figured out that they were receiving an intervention rather than placebo), the drug was not effective in depression treatment.