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Antipsychotics Lead to Worse Outcomes in First-Episode Psychosis

Mad in America

This included 3714 adolescents ages 13-20 who received a diagnosis of a psychotic disorder between 2003 and 2013 and had never before taken antipsychotic drugs. Researchers have found that cognitive-behavioral therapy without antipsychotics is just as effective for first-episode psychosis—that adding drugs provided no additional improvement.